Avner Schlessinger: search on Z-Library

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1

Identification of newborns at risk for autism using electronic medical records and machine learning

Rahman, Rayees, Kodesh, Arad, Levine, Stephen Z., Sandin, Sven, Reichenberg, Abraham, Schlessinger, Avner

Journal:

European Psychiatry

Year:

2020

Language:

english

File:

PDF, 502 KB

english, 2020

2

A whole-animal platform to advance a clinical kinase inhibitor into new disease space

Sonoshita, Masahiro, Scopton, Alex P, Ung, Peter M U, Murray, Matthew A, Silber, Lisa, Maldonado, Andres Y, Real, Alexander, Schlessinger, Avner, Cagan, Ross L, Dar, Arvin C

Journal:

Nature Chemical Biology

Year:

2018

Language:

english

File:

PDF, 3.75 MB

english, 2018

3

Crystal Structure of a Ternary FGF-FGFR-Heparin Complex Reveals a Dual Role for Heparin in FGFR Binding and Dimerization

Joseph Schlessinger, Alexander N. Plotnikov, Omar A. Ibrahimi, Anna V. Eliseenkova, Brian K. Yeh, Avner Yayon, Robert J. Linhardt, Moosa Mohammadi

Journal:

Year:

2000

Language:

english

File:

PDF, 406 KB

english, 2000

4

Protein disorder — a breakthrough invention of evolution?

Avner Schlessinger, Christian Schaefer, Esmeralda Vicedo, Markus Schmidberger, Marco Punta, Burkhard Rost

Journal:

Current Opinion in Structural Biology

Year:

2011

Language:

english

File:

PDF, 432 KB

english, 2011

5

Ligand discovery from a dopamine D3 receptor homology model and crystal structure

Carlsson, Jens, Coleman, Ryan G, Setola, Vincent, Irwin, John J, Fan, Hao, Schlessinger, Avner, Sali, Andrej, Roth, Bryan L, Shoichet, Brian K

Journal:

Nature Chemical Biology

Year:

2011

Language:

english

File:

PDF, 2.81 MB

english, 2011

6

Structural basis for alternating access of a eukaryotic calcium/proton exchanger

Waight, Andrew B., Pedersen, Bjørn Panyella, Schlessinger, Avner, Bonomi, Massimiliano, Chau, Bryant H., Roe-Zurz, Zygy, Risenmay, Aaron J., Sali, Andrej, Stroud, Robert M.

Journal:

Year:

2013

Language:

english

File:

PDF, 3.58 MB

english, 2013

7

Human Concentrative Nucleoside Transporter 3 (hCNT3, SLC28A3) Forms a Cyclic Homotrimer

Stecula, Adrian, Schlessinger, Avner, Giacomini, Kathleen M., Sali, Andrej

Journal:

Year:

2017

Language:

english

File:

PDF, 4.12 MB

english, 2017

8

Large-Scale Analysis of Thermostable, Mammalian Proteins Provides Insights into the Intrinsically Disordered Proteome

Galea, Charles A., High, Anthony A., Obenauer, John C., Mishra, Ashutosh, Park, Cheon-Gil, Punta, Marco, Schlessinger, Avner, Ma, Jing, Rost, Burkhard, Slaughter, Clive A., Kriwacki, Richard W.

Journal:

Journal of Proteome Research

Year:

2009

Language:

english

File:

PDF, 921 KB

english, 2009

9

Predicting the Functions and Specificity of Triterpenoid Synthases: A Mechanism-Based Multi-intermediate Docking Approach

Tian, Bo-Xue, Wallrapp, Frank H., Holiday, Gemma L., Chow, Jeng-Yeong, Babbitt, Patricia C., Poulter, C. Dale, Jacobson, Matthew P., Schlessinger, Avner

Journal:

PLoS Computational Biology

Year:

2014

Language:

english

File:

PDF, 4.30 MB

english, 2014

10

Correction: Generation of G protein-coupled receptor antibodies differentially sensitive to conformational states

Heimann, Andrea S., Gupta, Achla, Gomes, Ivone, Rahman, Rayees, Schlessinger, Avner, Ferro, Emer S., Unterwald, Ellen M., Devi, Lakshmi A.

Journal:

Year:

2018

Language:

english

File:

PDF, 212 KB

english, 2018

11

Coenzyme Q Biosynthesis: Evidence for a Substrate Access Channel in the FAD-Dependent Monooxygenase Coq6

Ismail, Alexandre, Leroux, Vincent, Smadja, Myriam, Gonzalez, Lucie, Lombard, Murielle, Pierrel, Fabien, Mellot-Draznieks, Caroline, Fontecave, Marc, Schlessinger, Avner

Journal:

PLoS Computational Biology

Year:

2016

Language:

english

File:

PDF, 6.28 MB

english, 2016

12

Proteome-scale relationships between local amino acid composition and protein fates and functions

Cascarina, Sean M., Ross, Eric D., Schlessinger, Avner

Journal:

PLoS Computational Biology

Year:

2018

Language:

english

File:

PDF, 12.13 MB

english, 2018

13

SLC Transporters: Structure, Function, and Drug Discovery

Colas, Claire, Ung, Peter Man-Un, Schlessinger, Avner

Journal:

Year:

2016

Language:

english

File:

PDF, 2.06 MB

english, 2016

14

DFGmodel: Predicting Protein Kinase Structures in Inactive States for Structure-Based Discovery of Type-II Inhibitors

Man-Un Ung, Peter, Schlessinger, Avner

Journal:

Biophysical Journal

Year:

2015

Language:

english

File:

PDF, 39 KB

english, 2015

15

S62. Neurotransmitter-Wide Association Study of Prenatal Exposure to Medication With Autism Spectrum Disorder

Janecka, Magdalena, Kodesh, Arad, Levine, Stephen, Lusskin, Shari, Viktorin, Alexander, Rahman, Rayees, Buxbaum, Joseph, Schlessinger, Avner, Sandin, Sven, Reichenberg, Avi

Journal:

Biological Psychiatry

Year:

2018

Language:

english

File:

PDF, 45 KB

english, 2018

16

Using multiple structure alignments, fast model building, and energetic analysis in fold recognition and homology modeling

Donald Petrey, Zhexin Xiang, Christopher L. Tang, Lei Xie, Marina Gimpelev, Therese Mitros, Cinque S. Soto, Sharon Goldsmith-Fischman, Andrew Kernytsky, Avner Schlessinger, Ingrid Y.Y. Koh, Emil Alexo

Journal:

Proteins: Structure, Function, and Bioinformatics

Year:

2003

Language:

english

File:

PDF, 227 KB

english, 2003

17

Large-scale Analysis of Thermo-stable, Mammalian Proteins Provides Insights into the Intrinsically Disordered Proteome

Galea, Charles A., High, Anthony, Obenauer, John C., Mishra, Ashutosh, Park, Cheon-Gil, Punta, Marco, Schlessinger, Avner, Ma, Jing, Rost, Buckhard, Otieno, Steve, Slaughter, Clive A., Kriwacki, Richa

Journal:

Biophysical Journal

Year:

2009

Language:

english

File:

PDF, 36 KB

english, 2009

18

Novel selective thiadiazine DYRK1A inhibitor lead scaffold with human pancreatic β-cell proliferation activity

Kumar, Kunal, Man-Un Ung, Peter, Wang, Peng, Wang, Hui, Li, Hailing, Andrews, Mary K., Stewart, Andrew F., Schlessinger, Avner, DeVita, Robert J.

Journal:

European Journal of Medicinal Chemistry

Year:

2018

Language:

english

File:

PDF, 1.39 MB

english, 2018

19

KinaMetrix: a web resource to investigate kinase conformations and inhibitor space

Rahman, Rayees, Ung, Peter Man-Un, Schlessinger, Avner

Journal:

Nucleic Acids Research

Year:

2018

Language:

english

File:

PDF, 2.79 MB

english, 2018

20

Computing Substrate Selectivity in a Peptide Transporter

Colas, Claire, Smith, David E., Schlessinger, Avner

Journal:

Cell Chemical Biology

Year:

2016

Language:

english

File:

PDF, 405 KB

english, 2016

21

SLC16 Family: From Atomic Structure to Human Disease

Bosshart, Patrick D., Charles, Roch-Philippe, Garibsingh, Rachel-Ann A., Schlessinger, Avner, Fotiadis, Dimitrios

Journal:

Trends in Biochemical Sciences

Year:

2020

File:

PDF, 1.43 MB

2020

22

Structure-Based Identification of Inhibitors for the SLC13 Family of Na + /Dicarboxylate Cotransporters

Colas, Claire, Pajor, Ana M., Schlessinger, Avner

Journal:

Year:

2015

Language:

english

File:

PDF, 1.15 MB

english, 2015

23

Ligand Discovery for the Alanine-Serine-Cysteine Transporter (ASCT2, SLC1A5) from Homology Modeling and Virtual Screening

Colas, Claire, Grewer, Christoph, Gameiro, Armanda, Albers, Thomas, Singh, Kurnvir, Otte, Nicholas J., Shere, Helen, Massimiliano, Bonomi, Holst, Jeff, Schlessinger, Avner

Journal:

Biophysical Journal

Year:

2015

Language:

english

File:

PDF, 43 KB

english, 2015

24

iDrug: Integration of drug repositioning and drug-target prediction via cross-network embedding

Chen, Huiyuan, Cheng, Feixiong, Li, Jing, Schlessinger, Avner

Journal:

PLoS Computational Biology

Year:

2020

File:

PDF, 3.39 MB

2020

25

Comparison of human solute carriers

Avner Schlessinger, Pär Matsson, James E. Shima, Ursula Pieper, Sook Wah Yee, Libusha Kelly, Leonard Apeltsin, Robert M. Stroud, Thomas E. Ferrin, Kathleen M. Giacomini, Andrej Sali

Journal:

Protein Science

Year:

2010

Language:

english

File:

PDF, 1.79 MB

english, 2010

26

DFGmodel: Predicting Protein Kinase Structures in Inactive States for Structure-Based Discovery of Type-II Inhibitors

Ung, Peter Man-Un, Schlessinger, Avner

Journal:

ACS Chemical Biology

Year:

2015

Language:

english

File:

PDF, 5.25 MB

english, 2015

27

LAT-1 activity of meta-substituted phenylalanine and tyrosine analogs

Augustyn, Evan, Finke, Karissa, Zur, Arik A., Hansen, Logan, Heeren, Nathan, Chien, Huan-Chieh, Lin, Lawrence, Giacomini, Kathleen M., Colas, Claire, Schlessinger, Avner, Thomas, Allen A.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2016

Language:

english

File:

PDF, 1.26 MB

english, 2016

28

Interaction of Bacillus subtilis Polynucleotide Phosphorylase and RNase Y

Salvo, Elizabeth, Alabi, Shanique, Liu, Bo, Schlessinger, Avner, Bechhofer, David H.

Journal:

Journal of Biological Chemistry

Year:

2016

Language:

english

File:

PDF, 2.29 MB

english, 2016

29

Integrated computational and Drosophila cancer model platform captures previously unappreciated chemicals perturbing a kinase network

Ung, Peter M. U., Sonoshita, Masahiro, Scopton, Alex P., Dar, Arvin C., Cagan, Ross L., Schlessinger, Avner, Mac Gabhann, Feilim

Journal:

PLoS Computational Biology

Year:

2019

File:

PDF, 8.84 MB

2019

30

Co-expression and co-localization of hub proteins and their partners are encoded in protein sequence

Feiglin, Ariel, Ashkenazi, Shaul, Schlessinger, Avner, Rost, Burkhard, Ofran, Yanay

Journal:

Molecular BioSystems

Year:

2014

Language:

english

File:

PDF, 1.52 MB

english, 2014

31

Structure-based discovery of prescription drugs that interact with the norepinephrine transporter, NET

Avner Schlessinger, Ethan Geier, Hao Fan, John J. Irwin, Brian K. Shoichet, Kathleen M. Giacomini and Andrej Sali

Journal:

Proceedings of the National Academy of Sciences

Year:

2011

Language:

english

File:

PDF, 1.36 MB

english, 2011

32

Modeling of the axon plasma membrane structure and its effects on protein diffusion

Zhang, Yihao, Tzingounis, Anastasios V., Lykotrafitis, George, Schlessinger, Avner

Journal:

PLoS Computational Biology

Year:

2019

File:

PDF, 3.35 MB

2019

33

Ligand-Target Prediction by Structural Network Biology Using nAnnoLyze

Martínez-Jiménez, Francisco, Marti-Renom, Marc A., Schlessinger, Avner

Journal:

PLoS Computational Biology

Year:

2015

Language:

english

File:

PDF, 3.75 MB

english, 2015

34

Advances and Challenges in Rational Drug Design for SLCs

Garibsingh, Rachel-Ann A., Schlessinger, Avner

Journal:

Trends in Pharmacological Sciences

Year:

2019

File:

PDF, 1.98 MB

2019

35

Modulation of Calmodulin Lobes by Different Targets: An Allosteric Model with Hemiconcerted Conformational Transitions

Lai, Massimo, Brun, Denis, Edelstein, Stuart J., Le Novère, Nicolas, Schlessinger, Avner

Journal:

PLoS Computational Biology

Year:

2015

Language:

english

File:

PDF, 1.97 MB

english, 2015

36

GEN3VA: aggregation and analysis of gene expression signatures from related studies

Gundersen, Gregory W., Jagodnik, Kathleen M., Woodland, Holly, Fernandez, Nicholas F., Sani, Kevin, Dohlman, Anders B., Ung, Peter Man-Un, Monteiro, Caroline D., Schlessinger, Avner, Ma’ayan, Avi

Journal:

BMC Bioinformatics

Year:

2016

Language:

english

File:

PDF, 2.55 MB

english, 2016

37

Detecting similar binding pockets to enable systems polypharmacology

Duran-Frigola, Miquel, Siragusa, Lydia, Ruppin, Eytan, Barril, Xavier, Cruciani, Gabriele, Aloy, Patrick, Schlessinger, Avner

Journal:

PLoS Computational Biology

Year:

2017

Language:

english

File:

PDF, 3.38 MB

english, 2017

38

Dopamine transporter oligomerization involves the scaffold domain, but spares the bundle domain

Jayaraman, Kumaresan, Morley, Alex N., Szöllősi, Daniel, Wassenaar, Tsjerk A., Sitte, Harald H., Stockner, Thomas, Schlessinger, Avner

Journal:

PLoS Computational Biology

Year:

2018

Language:

english

File:

PDF, 36.76 MB

english, 2018

39

Novel selective thiadiazine DYRK1A inhibitor lead scaffold with human pancreatic β-cell proliferation activity

Kumar, Kunal, Man-Un Ung, Peter, Wang, Peng, Wang, Hui, Li, Hailing, Andrews, Mary K., Stewart, Andrew F., Schlessinger, Avner, DeVita, Robert J.

Journal:

European Journal of Medicinal Chemistry

Year:

2018

File:

PDF, 1.39 MB

2018

40

High-Resolution Structure and Inhibition of the Schizophrenia-Linked Pseudokinase ULK4

Khamrui, Susmita, Ung, Peter M. U., Secor, Cody, Schlessinger, Avner, Lazarus, Michael B.

Journal:

Journal of the American Chemical Society

Year:

2019

File:

PDF, 1.62 MB

2019

41

Natively Unstructured Loops Differ from Other Loops

Schlessinger, Avner, Liu, Jinfeng, Rost, Burkhard

Journal:

PLoS Computational Biology

Year:

2007

Language:

english

File:

PDF, 585 KB

english, 2007

42

Redefining the Protein Kinase Conformational Space with Machine Learning

Ung, Peter Man-Un, Rahman, Rayees, Schlessinger, Avner

Journal:

Cell Chemical Biology

Year:

2018

Language:

english

File:

PDF, 3.27 MB

english, 2018

43

Structure-Based Ligand Discovery for Solute Carrier Transporters

Schlessinger, Avner

Journal:

Biophysical Journal

Year:

2013

Language:

english

File:

PDF, 35 KB

english, 2013

44

Description of the Structural Determinants of the hPepT1-Ligand Interactions

Colas, Claire, Schlessinger, Avner

Journal:

Biophysical Journal

Year:

2014

Language:

english

File:

PDF, 46 KB

english, 2014

45

High-Resolution Modeling of Transmembrane Helical Protein Structures from Distant Homologues

Chen, Kuang-Yui M., Sun, Jiaming, Salvo, Jason S., Baker, David, Barth, Patrick, Schlessinger, Avner

Journal:

PLoS Computational Biology

Year:

2014

Language:

english

File:

PDF, 1.65 MB

english, 2014

46

Structure activity relationships of benzylproline-derived inhibitors of the glutamine transporter ASCT2

Singh, Kurnvir, Tanui, Rose, Gameiro, Armanda, Eisenberg, Gilad, Colas, Claire, Schlessinger, Avner, Grewer, Christof

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2017

Language:

english

File:

PDF, 963 KB

english, 2017

47

Mapping Functionally Important Residues in the Na + /Dicarboxylate Cotransporter, NaDC1

Colas, Claire, Schlessinger, Avner, Pajor, Ana M.

Journal:

Year:

2017

Language:

english

File:

PDF, 5.45 MB

english, 2017

48

Ligand Discovery for the Alanine-Serine-Cysteine Transporter (ASCT2, SLC1A5) from Homology Modeling and Virtual Screening

Colas, Claire, Grewer, Christof, Otte, Nicholas James, Gameiro, Armanda, Albers, Thomas, Singh, Kurnvir, Shere, Helen, Bonomi, Massimiliano, Holst, Jeff, Schlessinger, Avner, Ben-Tal, Nir

Journal:

PLoS Computational Biology

Year:

2015

Language:

english

File:

PDF, 4.98 MB

english, 2015

49

Association of Autism Spectrum Disorder With Prenatal Exposure to Medication Affecting Neurotransmitter Systems

Janecka, Magdalena, Kodesh, Arad, Levine, Stephen Z., Lusskin, Shari I., Viktorin, Alexander, Rahman, Rayees, Buxbaum, Joseph D., Schlessinger, Avner, Sandin, Sven, Reichenberg, Abraham

Journal:

JAMA Psychiatry

Year:

2018

Language:

english

File:

PDF, 758 KB

english, 2018

50

Structures of ligand-occupied β-Klotho complexes reveal a molecular mechanism underlying endocrine FGF specificity and activity

Kuzina, Ekaterina S., Ung, Peter Man-Un, Mohanty, Jyotidarsini, Tome, Francisco, Choi, Jungyuen, Pardon, Els, Steyaert, Jan, Lax, Irit, Schlessinger, Avner, Schlessinger, Joseph, Lee, Sangwon

Journal:

Proceedings of the National Academy of Sciences

Year:

2019

Language:

english

File:

PDF, 2.89 MB

english, 2019

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